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G907 B

CAS No. 2244035-16-1

G907 B( —— )

Catalog No. M32932 CAS No. 2244035-16-1

G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

G907 B
Note

Research use only, not for human use.
Brief Description

G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide.
Description

G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

Antibiotic
Research Area

——
Indication

——

Chemical Information

CAS Number

2244035-16-1
Formula Weight

433.93
Molecular Formula

C26H24ClNO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (192.04 mM; Ultrasonic )
SMILES

CC(Oc1ccc2ncc(\C=C\C(O)=O)c(C3CC3)c2c1)c1c(Cl)cccc1C1CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.?

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